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11.Assessment of Coagulation Profile of Patients with Pregnancy Induced Hypertension Visiting Tertiary Care Hospital

Huda Abbas1, Sadia Bashir2, Hamad Masood1, Wajahat Hussain1, Arif Ahmed Zaidi1 and Sadaf Mushtaq1

ABSTRACT

Objective: To assess abnormalities in platelet count, PT (prothrombin time) and APTT (activated partial thromboplastin time) in patients with PIH.

Study Design: Cross sectional analytical study

Place and Duration of Study: This study was conducted at the department of Pathology in collaboration with Gynecology and Obstetrics Department of Bahawal Victoria Hospital from January, 2021 to June 2021 for a period of six months.

Materials and Methods: After approval from Institutional ethics review committee. All the women more than 28 weeks gestation having uncomplicated pregnancy with pregnancy induced hypertension visiting the hospital were included in the study. Pregnancy induced hypertension was defined as blood pressure at or above 140/90 mm of Hg on at least two occasions, six or more hours apart together with or without proteinuria, edema, convulsions and coma. Investigation done were platelet count, PT and APTT. Data entry was done in SPSS version 22.0. An independent sample t-test was used to check for differences in mean platelet count, PT & APTT between women with pregnancy induced hypertension (PIH) and without PIH and p-value <0.05 was set for statistical significance.

Results: Out of total 372 women 186 were cases of pregnancy induced hypertension while remaining 186 had no PIH. Maximum number of women in both groups were between 25 to 30 years of age. The mean age of women with PIH was 27.43±6.82 and women without PIH is 29.72±7.43 years. PIH was more common in primigravida women. The differences of prothrombin time (p<0.001) and Activated partial thromboplastin time (p<0.001) between two groups was statistically significant.

Conclusion: Patients with pregnancy-induced hypertension showed reduction in platelet count with increase PT and APTT in women with pregnancy induced hypertension.

Key Words: Platelet count, preeclampsia, Prothrombin Time, Platelet count

Citation of article: Abbas H, Bashir S, Masood H, Hussain W, Zaidi AA, Mushtaq S. Assessment of Coagulation Profile of Patients with Pregnancy Induced Hypertension Visiting Tertiary Care Hospital. Med Forum 2021;32(10):50-53.