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  3. 15.Efficacy of Atorvastatin (40mg) in Reducing Proteinuria in Chronic Kidney Disease (CKD) Patients
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15.Efficacy of Atorvastatin (40mg) in Reducing Proteinuria in Chronic Kidney Disease (CKD) Patients

Nafidullah Khan1, Raza Muhammad Khan1, Iftikhar Ali Khan2, Bughdad Khan2, Haider Ali Khan3 and Muhammad Nadeen Khan4

ABSTRACT

Objective: his study was planned to determine the efficacy of atorvastatin 40mg in reducing proteinuria in Chronic Kidney Disease patients, in our population at district Bannu and adjacent areas.

Study Design: Cross-Sectional, Descriptive

Place and Duration of Study: This study was conducted at the Department of Medicine/Nephrology, DHQ Teaching Hospital (DHDTH) Bannu, Khyber Pakhtunkhwa. Study was carried out for a period of 12 months, from July 2020 to June 2021.

Materials and Methods: The study was conducted on 246 patients presented to Department of Medicine/Nephrology, DHQ Teaching Hospital (DHDTH) Bannu, Khyber Pakhtunkhwa, who were having Hyperlipidemia (cholesterol>6mmol/L=232mg/dl, LDL-chol>2mmol/L=78mg/dl, TGs>1.9mmol/L=170mg/dl) and some CDK component (based on Proteinuria ie urinary protein excretion of > 150 mg per day). They were started on atorvastatin in the dose of 40mg once daily for hyperlipidemia for three months, and called for follow up after 3 months, to look for proteinuria.

Results: Treating dyslipidemia with atorvastatin 40mg/day not only reduced the risk of cardiovascular events but also aided in preventing the further deterioration of renal function in CKD cases. Our results revealed that atorvastatin in the dose of 40mg once daily for three months significantly reduced serum lipids and proteinuria in CKD patients.

Conclusion: In the light of above discussed evidences, it is concluded that atorvastatin 40mg once daily can be used in CKD patients to reduce hyperlipidemia and proteinuria. However, more detailed research is required in future to evaluate the dose dependent effect of atorvastatin in reducing proteinuria and to compare the efficacy of different statins in reducing the proteinuria in CKD patients.

Key Words: Atorvastatin, Proteinuria, Chronic Kidney Disease (CKD), Bannu

Citation of article: Khan N, Khan RM, Khan IA, Khan B, Khan HA, Khan MN. Efficacy of Atorvastatin (40mg) in Reducing Proteinuria in Chronic Kidney Disease (CKD) Patients. Med Forum 2021;32(8):64-68.