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17. Diagnostic Accuracy of Appendicitis Taking Histopathology as Gold Standard

Usman Asif1, Anam Zahira1, Haris Nasrullah2 and Suleman Asif1

ABSTRACT

Objective: To fix diagnostic accuracy Appendicitis score for diagnosis of acute appendicitis (AA) taking histopathology as gold standard.

Study Design: Interventional (clinical trial) study

Place and Duration of Study: This study was conducted at the Emergency Department of Ganga Ram Hospital, Lahore from 1st July 2016 to 31st December, 2016.

Materials and Methods: 315 patients fulfilling inclusion criteria. Their basic demographic information like name, sex, age and contact details was obtained after taking an informed consent from patients or attendants. Appendicitis score was calculated as per operational definition. The decision of appendicitis was taken by a single consultant to minimize bias. After operation / appendicectomy, the resected material /appendix was sent for final diagnosis to histopathology Lab of the hospital.  Then diagnosis on appendicitis and histopathology was compared to calculate diagnostic accuracy of appendicitis.

Results: The mean age of patients was 34.42 ± 9.43 years with age range of 18-60 years. There were 179(56.8%) male and 136(43.2%) female patients in this study, the male to female ratio was 1.31:1. Sensitivity, specificity, Positive Predictive Value and Negative Predictive Value of appendicitis  score keeping histopathology as gold standard was 96.68%, 90.91%, 98.5% and 81.63% respectively. The overall diagnostic accuracy of appendicitis score was 95.87%.

Conclusion: The sensitivity, specificity, Positive Predictive Value, Negative Predictive Value and overall diagnostic accuracy of appendicitis keeping histopathology as gold standard is high making it reliable and easier diagnostic tool.

Key Words: Appendix, surgery, histopathology, scoring system, Alvarado

Citation of articles: Asif  U, Zahira A, Nasrullah H, Asif S. Diagnostic Accuracy of Appendicitis Taking Histopathology as Gold Standard. Med Forum 2018;29(6):72-75.