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  3. 18. A Comparative Study Between Estrogen and Lipoproteins in Pre and Postmenopausal Hypertensive Women
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18. A Comparative Study Between Estrogen and Lipoproteins in Pre and Postmenopausal Hypertensive Women

Nosheen Aghani1, Nosheen Khaleeq1, Sarmad Jamal Siddiqui1, Habibullah Shaikh1,
Mehak Memon1 and Mehwish Memon2

ABSTRACT

Objective: To analyze the serum levels of estrogen and lipoproteins in pre and postmenopausal hypertensive women as compared to the normal healthy females.

Study Design: Comparative Cross sectional study

Place and Duration of Study: This study was conducted at the Biochemistry Department Peoples University of Medical Health Sciences for Women Nawabshah (PUMHSW) along the cooperation with Gynecology and Obstetrics and Medicine OPD/Ward PMCH from 1st July 2020 to 1st Jan 2022.

Materials and Methods: Blood samples were collected for biochemical testing and stored at -200C in the laboratory. Patients were recruited from the Gynecology and Obstetrics and Medicine OPD/Ward PMCH, whereas healthy volunteers were recruited from the general public by filling out a proforma. After explaining the study's goal to all participants, they gave their written and verbal agreement. This study involved 600 individuals who were separated into three groups. Using the ANOVA test, descriptive statistics were presented as mean and standard deviation. A test PEARSON was performed for correlation of serum estrogen and lipoproteins

Results: The serum oestrogen level was raised in normal, healthy females as compared to the pre- and postmenopausal participants. The level of the lipid profile was high in postmenopausal women in comparison with premenopause and the control group. The correlation between the serum oestrogen and lipid profile found a positive correlation of oestrogen with HDL-C and a negative correlation with total cholesterol, triglycerides, LDL-C, and the results showed an insignificant positive correlation of oestrogen with VLDL.

Conclusion: We concluded in this study that women after the menopause were at high risk of developing hypertension and other comorbidities, and the current study expected to understand the relationship of oestrogen level and lipid status in pre- and postmenopausal hypertensive women.

Key Words: Menopause, premenopause, postmenopause

Citation of article: Aghani N, Khaleeq N, Siddiqui SJ, Shaikh H, Memon M, Memon M. A Comparative Study between Estrogen and Lipoproteins in Pre and Postmenopausal Hypertensive Women. Med Forum 2023;34(2):80-83.