20.Frequency of GERD with Risk Regurgitation & Aspiration during Anesthesia in Different Age & Weight Groups with Their Histological Findings on Biopsy
Syed Sohail Abbas Naqvi1, Abdullah Khilji2, Munir Ahmad Channa3, Abdul Hayee Phulpoto4, Maqsood Ahmed Siddiqui5 and Syeda Abiya Amber Naqvi1
ABSTRACT
Objective: To determine the frequency of GERD with risk of regurgitation and aspiration during anesthesia in different age and weight groups with their histological findings on biopsy.
Study Design: Comparative / observational study
Place and Duration of Study: This study was conducted at the Department of Pathology, Civil Hospital, Khairpur Pakistan from 1st May 2021 to 30th November 2021.
Materials and Methods: One hundred and sixty patients of both genders were enrolled. Age of the patients was between 15-75 years. All the patients had gastro-esophageal reflux disease (GERD) were included. Patients were equally categorized into two groups. Group I had 80 patients with ages 15-40 years and above than 40 years of age were presented in group II. All the patients were underwent endoscopic biopsy under sedation/anesthesia. Findings among both groups were assessed in terms of risk of regurgitation and aspiration under anesthesia and histological findings were compared.
Results: The mean age in group I was 34.23±6.13 years and in group II mean age were 60.54±3.36 years. We found majority of the patients were males 55 (68.6%) and 51 (63.6%) among both groups. We found that severity of symptoms were higher in group I as compared to group II with p value <0.005. Esophagitis severity, barret esophagus and esophagus cancer were more prevalent in group II as per biopsy findings with p value <0.003. Frequency of hiatus hernia in group II was 32 (40%) higher as compared to group I 15 (18.6%) with p value < 0.004.
Conclusion: Rare and severity of symptoms were high in the group of patients presented with young age had GERD as compared to elder group but as per endoscopic biopsy under anesthesia findings severity of esophagitis, cancer, hiatus hernia, regurgitation and aspiration was more prevalent in the patients with ages >40 years had GERD as compared to young age patients with GERD.
Key Words: Gastro-esophageal reflux disease (GERD), Biopsy, Anesthesia, Clinical outcome, Symptoms
Citation of article: Naqvi SSA, Khilji A, Channa MA, Phulpoto AH, SiddiquiMA, Naqvi SAA. Frequency of GERD with Risk Regurgitation & Aspiration during Anesthesia in Different Age & Weight Groups with Their Histological Findings on Biopsy. Med Forum 2022;33(5):85-89.