1. Muhammad Ali Qureshi 2. Ghulam Rasool Bhurgri 3. Ghulam Mustafa Yousfani 

1. Asstt. Prof. of Anatomy, JMC, Peshawar 2. Prof. of Pharmacology and Therapeutics, MMS, Mirpur Khas 

3. Assoc. Prof. of Forensic Medicine, MMC, MMS, Mirpur Khas

ABSTRACT

Objective: To correlate the morphological and histo-pathological changes in placenta observed in normal, diabetic and hypertensive pregnancies.  Study Design: A cross sectional study

Place and Duration of Study: This study was carried at the department of Gynae and Obs Taluka hospital Hala, and Basic health unit Hala from 1^st January, 2014 to 30^th June, 2014

Materials and Methods: For this experimental study statistical analysis was carried on SPSS-11.0 version.Total 90 cases studied were divided in three equal groups. All placentae were processed through stages for final histopathological examination.

Results: The study showed that discoid shape were significantly less 4(13.3%) in hypertensive as compared to 16

(53.3%) diabetic and normal placentae (p<0.01), bilobed in 6 (20.0%) diabetic placenta. In hypertensive placenta

15(50%) had central attachment of umbilical cord, diabetic 22 (73.3%) and normal 30(100%).  Central thickness (Mean ± S.D ± SEM) of hypertensive placenta 2.2 ± 0.58 ± 0.11 were significantly less (p<0.01) as compared to normal placenta 3.0 ± 0.03 ± 0.01 but diabetic placenta 3.8 ± 1.15 ± 0.21 were significantly high (p<0.01) as compared to hypertensive and normal placenta.

Conclusion: Gestational diabetes and hypertension had significant t-test that causes morphological changes in placenta that affects fetal and maternal wellbeing. This study is helpful for those who are concerned for mother and child health.

Key Words: Hypertension, Diabetes, Pregnancy, Placenta