Sadia Sundus¹, Sarwath Fatimee⁵, Nadira Hameed¹, Jamil Ahmed Siddiqui², Imran Bakar³ and Shah Jabeen⁴

ABSTRACT

Objective: Toevaluate the nuclear diameter of proximal convoluted tubular cells in celecoxib impaired kidney with amelioration by lycopene.   Study design: Experimental study.

Place and Duration of study: This study was conducted in Animal House of BMSI, JPMC, Karachi from May 2015 to June 2015.

Materials and Methods: In this study we took 90-120 days old, forty healthy adult male Albino rats of 200-220gm weight. Rats were divided into 4 groups, control group was nominated as Group A, rats of Group B were given Celecoxib 50 mg/kg orally, rats of Group C were given Celecoxib 50 mg/kg with lycopene50 mg/kg and Group D were givenonly lycopene 50 mg/kg orally for 30 days. After the completion of experimental study, rats were dissected and renal tissue sections were stained with hematoxylin and eosin.

Results: The nuclei of renal cells became pyknotic and the cells showed apoptotic changes in rats of Group B. Hematoxylin and eosin stained sections showed apoptosis, hemorrhage, necrosis and vacuolation in Group B of albino rats, however renal structure were improved in Group Crats which were given celecoxib with lycopene. The proximal convoluted tubules of kidney became dilated due to apoptotic changes in renal cells and pyknosis of their nuclei. Renal interstitium showed inflammation, edemaand congestion.

Conclusion: This experimental study accomplishes that lycopene improved the pyknotic changes of Group B. Key Words: Apoptosis, reactive oxygen species (ROS), acute kidney injury (AKI), prostaglandins (PGs), interstitial nephritis (AIN), and glomerular filtration rate (GFR).

Citation of article: Sundus S, Fatimee S, Hameed N, Siddiqui JA, Bakar I, Jabeen S. Histomorphological Effect of Celecoxib on Nuclear Diameter of Proximal Convoluted Tubular Cells of Kidney with Ameliorative Effect of Lycopene in Albino Rats; An Experimental Study. Med Forum 2021;32(2):156-160.