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39. Association of Prolactin with Psoriasis in Out-Patients at a Tertiary Care Hospital

Nadia Rajper1, Muhammad Suleman Pirzado2, Hafiz Bashir Ahmed Kalhoro1,Tanweer Ahmed Shaikh3, Muhammad Yaqoob Shahani4 and Sanam Pirzado1

ABSTRACT

Objective: Psoriasis is a serious, persistent, disfiguring, inflammatory, and proliferative skin disorder. Prolactin (PRL), an anterior pituitary gland secreted neuropeptide, has a number of physiological and biochemical actions. It has been suggested that Prolactin may be involved in psoriasis development. Therefore, the study could help to look for hyperprolactinemia in psoriasis patients and thus take appropriate treatment measures to address the issue. The study's basic objective is to determine the mean amount of serum prolactin in psoriasis patients.

Study Design: Observational / cross sectional study

Place and Duration of Study: This study was conducted at the outpatient’s department (OPD) of Department of Dermatology, LUMHS Jamshoro & LMU hospital Sindh Pakistan from October 2015 to March, 2016.

Materials and Methods: This research included 42 confirmed cases of psoriasis. All these patients were tested by the ELISA technique of taking 3cc venous blood sample in a disposable syringe for serum prolactin level and sent it for analysis to the laboratory. On pre-designed pro forma, the patient data are collected.

Results: The average age was 37.71± 10.68 years. There were 40.48% male and 59.52% female. Mean serum prolactin level in patients of psoriasis was 44.21± 14.73 ng/ml (95%CI: 39.61 to 48.80).

Conclusion: The above findings indicate that the amount of serum prolactin may play a significant role in pathophysiology of psoriasis. In patients with psoriasis, we experienced a significant rise in serum PRL. We therefore could say that PRL can be used as a useful psoriatic behavioral biological marker.

Key Words: Psoriasis, Serum prolactin level, Hyperprolactinemia

Citation of article: Rajper N, Pirzado MS, Kalhoro HBA, Shaikh TA, Shahani MY, Pirzado S. Association of Prolactin with Psoriasis in Out-Patients at a Tertiary Care Hospital. Med Forum 2021;32(3):159-162.