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  3. 8. Effect of Glycemic Control on Homocystine Levels in Type 2 Diabetes Mellitus - A Six Month Follow-up Study
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8. Effect of Glycemic Control on Homocystine Levels in Type 2 Diabetes Mellitus - A Six Month Follow-up Study

Zulfania1, Soheb Rehman2 and Tahir Gaffar3

ABSTRACT

Objective: Review of the available reports is unable to determine with any certainty the association of glycemic control (HbA1c) and homocystine (Hcy)  in diabetes. Therefore, the present study was carried out to ascertain the relation of glycemic control with Hcy levels.

Study Design: Cohort study

Place and Duration of Study: This study was conducted at the Endocrinology Unit of Hayatabad Medical Complex (HMC). A laboratory analysis was done in the laboratory of Rehman Medical Institute (RMI), Peshawar from April 2015 to October 2015.

Materials and Methods: This cohort study was conducted on 125 patients who were known type 2 diabetics visiting Endocrinology unit of HMC. A detailed medical history and clinical examination was carried out to exclude co morbidities. At all three visits i.e baseline, first and second follow up HbA1c and Hcy were recorded. Statistical analysis of the data was done by SPSS version 20 using Pearson correlation test to correlate HbA1c levels with Hcy levels.

Results: The mean age of 125 study subjects was 51± 8.37 years,out of these 68% were females and 32% were males. The mean HbA1clevels reduced from baseline (9.64±2.25%) to (8.56±1.99%) till second follow up. Mean Hcy levels did not dropped from baseline (10.04±4.31) to second follow up (11.46±3.95), rather increased. There was no correlation of Hcy with HbA1c in baseline data (r=-0.052, p=0.576), first follow up (r=-0.023, p=0.836) and second follow up (0.098, p=0.521).  No correlation was also evident in change of Hcy and HbA1c levels noticed from baseline till second follow up.

Conclusion: The study concluded that there is no correlation of Hcy and HbA1c in baseline as well as follow
up data.

Key Words: HbA1c, glycemic control, , Hcy, Type 2 diabetes mellitus

Citation of articles: Zulfania, Rehman S, Gaffar T. Effect of Glycemic Control on Homocystine Levels in Type 2 Diabetes Mellitus - A Six Month Follow-up Study. Med Forum 2018;29(9):32-35.