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  3. 8.Incidence and Risk Factors for Low Bone Mineral Density in Inflammatory Bowel Disease
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8.Incidence and Risk Factors for Low Bone Mineral Density in Inflammatory Bowel Disease

Imran Arshad, Shaista Zeb, Ehsan Rahim Memon and Prem Kumar

ABSTRACT

Objective: Inflammatory bowel disease often causes osteoporosis. Inflammatory bowel disease patients' BMD falls due to clinical causes (IBD). Despite little data, BMD prevalence and risk factors are poorly known. Thus, this research investigated IBD's low BMD prevalence and causes.

Study Design: Cross-sectional study

Place and Duration of Study: This study was conducted at the Isra University Hospital's Gastroenterology Department included 65 adult ulcerative colitis patients from August 2021 to July 2022.

Materials and Methods: Patients' ages, BMIs, illnesses, sex, sickness durations, vitamin D levels, and steroid use histories were recorded. Dual-energy X-ray absorptiometry evaluated lumbar and femur bone mineral density (DEXA). Bone metabolism biochemical markers included deoxypyridinoline, serum calcium, osteocalcin, and phosphorus. Low bone mineral density was compared to medications, steroid usage, disease duration, age, and body mass index. SPSS 25 analyzed the data.

Results: The diagnosis of ulcerative colitis was made in 30 women (46.2% of the total) and 35 males (53.8% of the total). 38.6 3.54 years. 68.9% (n=45) had abnormal bone mineral density. 35.4% and 33.8% of 45 individuals with abnormal BMD had osteoporosis and osteopenia. Steroid use and illness duration substantially correlated with low bone mineral density in univariate analysis. Poor bone mineral density predicted disease duration in multivariate studies. Poor BMD was unrelated to age, body mass index, gender, vitamin D status, or steroid usage.

Conclusion: High levels of osteoporosis and osteopenia were seen in this study of people with inflammatory bowel disease. Poor bone mineral density was strongly associated with disease progression. Illness seems to be the biggest risk factor for low bone mineral density. Early detection of low MBD allows for prevention.

Key Words: Unknowns Inflammatory colitis, Bone deficiency

Citation of article: Arshad I, Zeb S, Memon ER, Kumar P. Incidence and Risk Factors for Low Bone Mineral Density in Inflammatory Bowel Disease. Med Forum 2022;33(11):32-35.