31.7.16 Evaluation of Serum Lipid Profile in Preeclampsia and Healthy Pregnant Women, Mirpur AJK

Original Article

 

Lipid Profile in Preeclampsia and Pregnant Women

Evaluation of Serum Lipid Profile in Preeclampsia and Healthy Pregnant Women, Mirpur AJK

Aurooj Fatima1, Aisha Yousaf2, Shakila Khadim3 and Asnad4

ABSTRACT

Objective: To evaluate Serum Lipid Profile in preeclampsia Patients   and normal pregnant women in Mirpur, AJK.

Study Design: Cross-sectional study

Place and Duration of Study: This study was conducted at the Department of Obstetrics and Gynaecology and Biochemistry, Mohtarma Benazir Bhutto Shaheed Medical College Mirpur AJK from January 2018 to July 2019.

Materials and Methods: We take for study 200 Preeclampsia patients and 100 health pregnant women. We take blood samples from both groups women and analyzed the samples on Microlab 300 for serum lipid profile. (Cholestol, HDL, LDL, VLDL and Triglyceride). For the study we use kits made of Merck Pvt. We also did other biochemistry test and hematological test.

Results: The result indicate that all the lipid profile (LDL, Triglyceride) is higher except HDL in women with as compare to normal pregnant women. Total cholesterol (254.5 ± 12.8) mg/dl, LDL (128.9 ± 21.5) mg/dl, and Triglyceride (199.2 ± 32.5) mg/dl, in Preeclampsia are higher as compare to normal pregnant women. While HDL (40.77± 8.5) mg/dl, is decreased in Preeclampsia as compare to normal pregnant women.

Conclusion: The result of this study it is conclude that pregnant women should adopt balanced diet and reduced the lipid profile and reduced their weight and change their life style and adopt healthy life style.

Key Words: Preeclampsia, Lipid profile, normal pregnant

Citation of article: Fatima A, Yousaf A, Khadim S and Asnad. Evaluation of Serum Lipid Profile in Preeclampsia and Healthy Pregnant Women, Mirpur AJK. Med Forum 2020;31(7):68-70.

 

 

INTRODUCTION

In pregnancy, Preeclampsia mostly causing complication and also relate with morbidity and mortality of perinatal and maternal.1   the worldwide percentage of Preeclampsia compilation is 7-10% of pregnancies.2 The percentage of raised blood pressure is different among the pregnant women 20-25% is exist in chronic hypertension previous history of pregnant women, 10% of primi parous women and 5% of entire pregnancies.3 pregnancy-induced hypertension (PIH) risk is increasing with increasing age of women.4 Dyslipidemia is also developing with  pregnancy-induced hypertension .5 For cardiovascular disease, independent risk factors,  are endothelial dysfunction  and Insulin resistance .6  

 

 

1. Department of Obstet and Gynae /Biochemistry2, Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur, AJK.

3. Department of Obstet and Gynae / Pathology4, Mohd ud din Medical College, Mirpur, AJK.

 

 

Correspondence: Dr. Asnad, Associate Professor of Biochemistry, Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur, AJK.

Contact No: 0332-3698204

Email: drasnadkhan@gmail.com

 

 

Received:    January, 2020

Accepted:    April, 2020

Printed:        July, 2020

 

 

In preeclampsia, it is observed that abnormal lipid profile produced vascular dysfunction and also oxidative stress  which caused  preeclampsia.7 There is evidence  is present t  that increasing  the lipid profile which ultimately caused preeclampsia. Especially when triglycerides and LDL (low-density lipoproteins) are increased in oxidized form in women.8  It is suggested that in pregnancy the estrogen synthesis is higher which increased the synthesis of triglyceride in liver and by hyperinsulinism it is modulated   and this process is occurred in pregnancy which ultimately caused endothelial cell damage.9In uterine spiral  arties, triglyceride  and dense LDL particles  are accumulate  due to more or three to four time more  triglycerisdes are synthesis and this caused endothelial  cell damage.10

In this study we evaluate lipid profile   preeclampsia patients   and compared to normal pregnant women in Mirpur AJK.

MATERIALS AND METHODS

We take for study 200 Preeclampsia patients and 100 health pregnant women. The study was conducted in the department of Obstetrics and gynaecology and Biochemistry Department of Mohtarma Benazir Bhutto Shaheed Medical College Mirpur AJk.  We take blood samples from both groups women and analyzed the samples on Microlab 300 for serum lipid profile. (Cholestol, HDL, LDL, VLDL and  Triglyceride). For the study we use kits made of Merck Pvt. We also done other biochemistry test and hematological test.

RESULTS

The result indicates that all the lipid profile (LDL, Triglyceride) is higher except HDL in women with as compare to normal pregnant women. Total cholesterol (254.5 ± 12.8) mg\dl, LDL (128.9 ± 21.5) mg\dl, and Triglyceride (199.2 ± 32.5) mg\dl, in Preeclampsia are higher as compare to normal pregnant women. While HDL (40.77± 8.5) mg\dl, is decreased in Preeclampsia as compare to normal pregnant women. Table 1.

Table No.1: Biochemical profile of Preeclampsia patients and Normal pregnant women

Preeclampsia Patients (n=200)

 

Normal  pregnant women (n=100) 

Fasting Blood Glucose(mg/dl)

 

97.8 ± 4.3

99.4 ± 4.6

Total Cholesterol (mg/dl)

 

254.5 ± 12.8

192.6 ± 31.5

LDL  (mg\dl)

 

128.9 ±  21.5

114.5± 18.3

HDL  (mg\dl)

 

40.77± 8.5

57.3 ± 9.1

Triglycerides (mg\dl)

 

199.2 ± 32.5

133.3 ± 31.2

DISCUSSION

In the study of Anjum there is high lipid profile in pregnant women as compare to normotensive women and it also observed that HDL is significantly low in pregnant women as compare to normotensive women.11 We take for study 200 Preeclampsia patients and 100 health pregnant women. The study was conducted in the department of Obstetrics and gynaecology and Biochemistry Department of Mohtarma Benazir Bhutto Shaheed Medical College Mirpur AJk.  We take blood samples from both groups women and analyzed the samples on Microlab 300 for serum lipid profile. (Cholestol, HDL, LDL, VLDL and  Triglyceride). For the study we use kits made of Merck Pvt. We also done other biochemistry test and hematological test.

 In pregnancy, endothelial dysfunction occurred it is due increased synthesis of triglyceride in liver it is conclude by Mikhail et al.12 In the study of Gohil et al., it is described that HDL is significantly decreases in preeclampsia as compared to non-pregnant while the other profile of lipid (Triglycerides, VLDL and LDL) is increased .13 In pregnancy, Preeclampsia mostly causing complication   and also relate with morbidity and mortality of perinatal and maternal.   the worldwide percentage of Preeclampsia compilation is 7-10% of pregnancies.

The percentage of raised blood pressure is differ among the pregnant women 20-25% is exist in chronic hypertension  previous history  of pregnant women, 10% of primi  parous women  and 5% of entire pregnancies.

pregnancy-induced hypertension (PIH) risk is increasing with increasing age of women. Dyslipidemia is also developing with pregnancy-induced hypertension. For cardiovascular disease, independent risk factors, are endothelial dysfunction and Insulin resistance.  In preeclampsia, it is observed that abnormal lipid profile produced vascular dysfunction and also oxidative stress which caused preeclampsia.7 There is evidence  is present   that increasing  the lipid profile which ultimately caused preeclampsia. Especially when triglycerides and LDL (low-density lipoproteins) are increased in oxidized form in women.  It is suggested that in pregnancy the estrogen synthesis is higher which increased the synthesis of triglyceride in liver and by hyperinsulinism it is modulated   and this process is occurred in pregnancy which ultimately caused endothelial cell damage. In uterine spiral arties  , triglyceride  and dense LDL particles  are accumulate  due to more or three to four time more  triglycerisdes are synthesis and this caused endothelial  cell damage. The result indicate that all the lipid profile (LDL, Triglyceride) is higher except HDL in women with  as compare to  normal pregnant women. Total cholesterol (254.5 ± 12.8) mg\dl, LDL (128.9 ± 21.5) mg\dl,  and Triglyceride (199.2 ± 32.5) mg\dl, in Preeclampsia are higher as compare to normal pregnant women. While HDL (40.77± 8.5) mg\dl, is decreased in Preeclampsia as compare to normal pregnant women. In the study  of  Enquobahrie et al he observed that triglyceride  is  significantly higher in  women  with  pre-eclampsia.14       Deshpande H et al   during his study  he found that  from Mild PIH to Severe PIH the lipid profile(cholesterol, LDL, VLDL and triglyceride ) is increased  and  also Severe PIH to  Eclampsia lipid profile(cholesterol, LDL, VLDL and triglyceride ) is increased and HDL Levels are decreased.15    The result of this study it is conclude that pregnant women should adopt balanced diet  and reduced the lipid profile and reduced their weight and change their life style  and adopt healthy life style.

CONCLUSION

The result of this study it is conclude that pregnant women should adopt balanced diet  and reduced the lipid profile and reduced their weight and change their life style  and adopt healthy life style.

Author’s Contribution:

Concept & Design of Study:

Aurooj Fatima

Drafting:

Aisha Yousaf

Data Analysis:

Shakila Khadim, Asnad

Revisiting Critically:

Aurooj Fatima,
Aisha Yousaf

Final Approval of version:

Aurooj Fatima

Conflict of Interest: The study has no conflict of interest to declare by any author.

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