32.1.11 Severe Umbilical Arterial Blood Metabolic Acidosis; A Predictor of Neonatal Encephalopathy

Original Article

 

Umbilical Arterial Blood and Neonatal Encephalopathy

Severe Umbilical Arterial Blood Metabolic Acidosis; A Predictor of Neonatal Encephalopathy

Syed Zulfiqar Haider1, Lubna Akhtar1, Mulazim Hussain1, Sayed Ibrar Hussain1, Nadeem Ahmed2 and Syed Mohammad Aleem Haider1

ABSTRACT

Objective: To determine the relationship of Severe Umbilical Arterial Blood Metabolic Acidosis to Neonatal Encephalopathy.

Study Design: Descriptive cross sectional study

Place and Duration of Study: This study was conducted at the Department of Pediatrics, Fauji Foundation Hospital, Rawalpindi, over a period of 6 months from April, 2019 to Oct, 2019.

Materials and Methods: Umbilical arterial blood (UAB), samples were collected from all full term, singleton babies of both sexes, delivered by all delivery types, soon after birth. Non-probability consecutive sampling technique was used. Arterial blood gas analysis of these samples was done within half an hour, and babies with severe acidosis in UAB i.e. pH less than 7.0, were separated and included in this study. These neonates were observed for the development of signs of neonatal encephalopathy (NE). A comparison of acid base parameters, including pH, HCO3, and base deficit of these samples was made in neonates who developed NE versus those who did not. A relationship between these parameters and development of NE was established.

Results: It was found that 28.9% (24/83) of neonates with severe metabolic acidosis developed signs of NE within two days of birth. The mean pH and HCO3 were significantly low and BE was significantly high in these neonates; p =0.000.

Conclusion: Severe metabolic acidosis detected in umbilical arterial blood in a new born is an indicator of impending neonatal encephalopathy.

Key Words: Neonatal encephalopathy, umbilical arterial blood, metabolic acidosis.

Citation of article: Severe Umbilical Arterial Blood Metabolic Acidosis; A Predictor of Neonatal Encephalopathy. Med Forum 2021;32(1):44-47.

 

 

INTRODUCTION

Increased or decreased body tone and seizures in a new born are indicators of neonatal encephalopathy (NE). NE is a clinical manifestation of neonatal brain dysfunction (NBD), and it can occur due to different etiologies. It occurs due to structural malformations of the brain, infections, metabolic derangements and hypoxia. Hypoxia can lead to serious NBD and NE. Hypoxic ischemic encephalopathy (HIE) resulting from perinatal fetal ischemia (PFI) is the most common cause of NBD and NE1-2.

 

 

1. Department of Pediatrics, Foundation University Medical College, Islamabad.

1. Department of Pediatrics, Children Hospital, PIMS, Islamabad.

 

 

Correspondence: Dr. Syed Zulfiqar Haider, Assistant Professor Pediatrics, Foundation University Medical College Islamabad & Fauji Foundation Hospital Rawalpindi.

Contact No: 0333-5107659

Email: drsyedzulfiqarhaider@gmail.com

 

 

Received:  August, 2020

Accepted:  October, 2020

Printed:      January, 2021

 

 

The incidence of NE in different studies is 2.0 to 6.0 per 1000 live births3-6, and that of HIE is also 2.0 to 6.0 per 1000 live births.7-15

NE is a fairly common occurrence in neonates and results in adverse neurological outcomes later in life3. In one international study 167 term neonates with HIE were followed for a period of 3-5 years, 23.3% of these neonates got neurologically affected. Ones with moderate HIE developed cerebral palsy and those with severe HIE developed profoundly handicap11.

Management planning to minimize adverse neurological outcomes later in life of children suffering from hypoxia in perinatal period, demands an early detection of PFI. In significant PFI the umbilical arterial blood (UAB) has severe metabolic acidosis (MA) with a pH of <7.0, and leads to HIE in 31% patients12. Umbilical arterial blood MA can be detected by performing blood gas analysis (BGA) of a fresh UAB sample. The objective of this study was to identify neonates at risk of developing NE by doing arterial blood gas analysis.

MATERIALS AND METHODS

This study was carried out in the Department of Pediatric Medicine, Fauji Foundation Hospital Rawalpindi, from 22nd April to 23rd Oct 2019, after taking approval from the hospital ethical committee. Non probability consecutive sampling technique was used to collect umbilical arterial blood samples from full term babies delivered by all delivery types. Within half an hour of sampling the samples were sent to hospital laboratory for blood gas analysis and the results were recorded separately for each patient.  After taking informed consent from parents, eighty three babies with severe metabolic acidosis i.e. pH less than 7.0, were included in the study.

The selected babies were observed for development of hypotonia, hypertonia and/or seizures. Babies with respiratory acidosis, neonatal sepsis, cardiac or renal disease, and family history of inborn errors of metabolism were excluded from the study. The relationship of umbilical arterial blood parameters including pH, HCO3, and base deficit, was studied against the development of neurological signs. These neonates were kept under observation and discharged once clinically stable and tolerating oral feeds.

The data was analyzed on SPSS version 16.0. Descriptive statistics were used to measure qualitative and quantitative data. Qualitative data were measured by percentages and frequencies and quantitative data was measured as mean ± standard deviation (SD) and if the data were normally distributed, by median and range otherwise.

RESULTS

Mean, median, mode and standard deviation of pH, bicarbonate (HCO3) & base excess (BE) of the umbilical arterial blood samples of the neonates included in the study were calculated.  (table-1).

Table No.1: Descriptive statistics for umbilical artery acid base parameters

 

pH

HCO3

BE

Mean

6.86

7.7241

-22.62

Median

6.89

8.10

-22.20

Mode

6.79

8.20

-20.90

Std. Deviation

0.13

1.53

2.37

Minimum

6.00

3.40

-28.20

Maximum

6.99

10.60

-18.60

The umbilical arterial blood, acid base parameters were compared in neonates who developed NE versus those who did not (table-2). It was found that out of the eighty three babies with severe umbilical arterial blood metabolic acidosis, 24 (28.9%) developed neonatal encephalopathy within two days of birth. The acid base parameters of these neonates showed pH 6.75±.20, HCO3 5.98±1.22 and BE -24.71±1.96. The mean pH and HCO3 of these neonates were significantly lower and mean BE was significantly higher; p =0.000.

Table No.2: Umbilical arterial acid base parameters in neonates with Hypoxic ischemic encephalopathy versus neonates with no neurological sign

Umbilical arterial blood acid base parameters

Hypoxic ischemic

Encephalo-pathy

No neurological sign

 

P value

pH

6.75±.20

6.90±0.06

0.00

HCO3

5.98±1.22

8.43±0.99

0.00

BE

-24.71±1.96

-21.77±1.97

0.00

DISCUSSION

Adverse neurological outcomes associated with NE include cerebral palsy, epilepsy, cognitive, developmental and behavioral problems, and even death3. Ethical, social, legal, and financial costs involved in such outcomes are enormous13,14. This necessitates testing and early detection of NE, especially due to perinatal fetal ischemia (PFI), in order to improve perinatal care and to take timely decisions of intervention16.

For the early detection of perinatal fetal ischemia, different investigations are done including umbilical arterial blood gases for metabolic acidosis, Apgar score, serum lactate, placental histology, heart rate decelerations, electrocardiographic & cardiotocographic monitoring, MRI and electroencephalogram of newborns16-22. These parameters are used in different combinations depending upon availability of resources in a particular setup and this significantly increases the possibility to diagnose NE.

Among these investigations UAB metabolic acidosis has been consistently included by majority of criteria for diagnosis of perinatal ischemia and is considered the single most sensitive indicator of intrapartum fetal ischemia by the British and American Colleges of Obstetrics and Gynecology23

In a study done by Wayenberg, moderate or severe NE occurred in 26% of patients with UAB base deficit higher than 10mmol/L and in 79% of those with base deficit higher than 18mmol/L. In our study 28.9% neonates developed clinical signs of NE and they had base deficit 18.60 to 28.20 mmol/L with SD 2.37. The similarity in two studies is higher percentage of neonates developing NE with a rising base deficit. A difference in base deficit values of the two studies can be noted and it is explainable by the fact that base deficit values are calculated entities and not measured ones and are therefore are subject to variation16.

V Modarressnejad at Kerman University of Medical and Health Sciences, Iran, conducted a prospective cross-sectional study. Four hundred singleton term babies delivered by all delivery types were included in the study. Mean (SD) umbilical cord blood pH was 7.25 +/- 0.14. Eighty-one of these patients showed pH <7.1. This low pH was found related to development of poor neurological outcomes. Our inclusion criteria was babies with severe metabolic acidosis, UAB pH <7.0, thus umbilical cord blood pH mean (SD) in our study was 6.86 +/- 0.13 and range 6.00 to 6.99, SD 0.13. In our study neonates, who developed signs of NE, had pH 6.75±.20. The pH values of the two studies for the affected children are in keeping with each other.24

Victory R, using database of St. Joseph's Health Care, London, studied term neonates for a relationship of umbilical cord arterial & venous blood pH and base deficit along with Apgar score <7 at 5 minutes, to the chances of intensive care unit admissions & need for mechanical ventilation. A progressively higher risk with increasing metabolic acidosis was found. This relationship was independent of whether the blood was taken from the umbilical artery or vein. Our study with all its simplicity reached the same conclusion of increased risk with increasing metabolic acidosis. We monitored only clinical signs of NE and yet the results were similar, and this was indeed an advantage for our local setups25.

Our study was exquisitely simple, conducted in available hospital resources and needed no additional funding from any agency. This excluded possible bias related to cost and benefit gains. Moreover, it is applicable in most hospital settings of Pakistan and provides opportunity to improve management & outcome. The short coming of our study was that the affected neonates were followed only for a short period of time, i.e. till stability and discharge, and late complications and outcomes were not monitored. Though it was beyond the scope of our study, it would be worth doing in a future.

CONCLUSION

Severe metabolic acidosis in umbilical arterial blood of a neonate, detected soon after birth, is a reasonably reliable indicator of ischemia and predictor of impending neonatal encephalopathy. It can be used to treat these newborns and improve outcome.

Author’s Contribution:

Concept & Design of Study:

Syed Zulfiqar Haider

Drafting:

Lubna Akhtar, Mulazim Husssain

Data Analysis:

Sayed Ibrar Hussain, Nadeem Ahmed, Syed Mohammad Aleem Haider

Revisiting Critically:

Syed Zulfiqar Haider, Lubna Akhtar

Final Approval of version:

Syed Zulfiqar Haider

Conflict of Interest: The study has no conflict of interest to declare by any author.

 

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