32.1.9 Evaluation of Serum Lipid Profile in Male Hypertensive Population

Original Article

 

Lipid Profile in Male Hypertensive

Evaluation of Serum Lipid Profile in Male Hypertensive Population

Rana Tauqir Ullah Khan1, Fouzia Qadir2 and Muhammad Irfan Shereen3

ABSTRACT

Objective: The objective of this study to evaluate serum lipid profile in Male hypertensive population as compare to control.

Study Design: Cross-sectional study 

Place and Duration of Study: This study was conducted at the community of medicine of Muhammad College of Medicine, Peshawar and Department of Biochemistry, Northwest school of medicine, Peshawar from January 2018 to September 2019.

Materials and Methods: Total 200 Male patients were selected male and 100 control health people are selected for the study. Lipid profile (Total cholesterol, HDL, VLDL and triglycerides) was estimated in both groups in male patient and control healthy people. Blood samples were collected from both groups’ male hypertensive patient   and health people. Samples were analyzed by Micro lab 300 for lipid profile for both groups male hypertensive patient and control .Merck kits were used for analysis of lipid profile in both groups.

Results: In male hypertensive patients the serum lipid profile is higher as compare to control health male except c\HDL which is decreased in hypertensive patients and high in male control which have vasoprotective effect. The mean of total cholesterol (256.5 ± 12.9) is higher in male hypertensive patients as compare to healthy control.  The mean of total LDL (mg\dl)   (130.8 ± 21.5) is higher in male hypertensive patients as compare to healthy control. The mean of total Triglycerides (mg\dl) (190.2 ± 32.6) is higher in male hypertensive patients as compare to healthy control. The mean of total HDL (mg\dl)   (30.6± 8.7) is lower in male hypertensive patients as compare to healthy control.

Conclusion: Male hypertensive patient found high level of serum lipid profile, so at high risk of cardiovascular diseases.  It is may be their life style or metabolic system.

Key Words: Serum Lipid profile, male hypertensive population

Citation of article: Khan RTU, Qadir F, Shereen MI. Evaluation of Serum Lipid Profile in Male Hypertensive Population. Med Forum 2021;32(1):36-39.

 

 

INTRODUCTION

Hypertension major risk factors for cardiovascular disease (CVD) are   dyslipidemia and Hypertension .Rate of death is high in low- and middle income countries at least 80%.1, 2In the developing countries, prevalence of hypertension is increasing globally it in developed countries the rate of death from hypertension is higher as compare to developed countries.2High blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides (TG) are attached with hypertension and CVD.

 

 

1. Department of Community Medicine, Muhammad College of Medicine, Peshawar.

2. Department of Biochemistry, Northwest School of Medicine, Peshawar.

3. Department of Physiology, IBMS, KMU, Peshawar.

 

 

Correspondence: Dr.  Asnad, Associate Professor of Biochemistry, Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur, AJK.

Contact No: 0332-3698204

Email: drasnadkhan@gmail.com

 

 

Received:  September, 2020

Accepted:  November, 2020

Printed:      January, 2021

 

 

In contrast, a risk factor for mortality from CVD is low level of high density lipoprotein (HDL).3(Hypertension and coronary artery disease) has established association as Epidemiological studies.4 34% is prevalence of hypertension among adult   worldwide.5,6 Major risk factors for CVD are decreased HDL and increased TC, TG, LDL. 7Reasons of Coronary heart disease in man population isHyperlipidemia.8, On the surface of the heart ,there is  four primary coronary arteries .9,10 CHD is   high ratio in man as compare women CHD is high in male population.11,12 Reasons of cardiovascular disease  are total cholesterol, triglyceride, HDL, LDL.13 Vasoprotective effects is increased by HDL, with high levels of cholesterol in blood circulation is associated with progression of heart disease.14,15 Risk factors of CHD are modifiable.16 High level of lipid is mostly occurring factor of  Hypertension.17 The objective of this study to evaluate  serum lipid profile in   Male hypertensive  population   as compare  to control.

MATERIALS AND METHODS

This study is conducted in the department of community medicine of Muhammad College of Medicine, Peshawar and Department of Biochemistry, Northwest school of medicine, Peshawar.  It was cross section–control study. Total 200Male patients were selected male and 100 control health people are selected for the study. Lipid profile (Total cholesterol, HDL, VLDL and triglycerides) was estimated in both groups in male patient and control healthy people. Blood samples were collected from both groups’ male hypertensive patient   and health people. Samples were analyzed by Micro lab 300 for lipid profile for both groups male hypertensive patient and control. Merck kits were used for analysis of lipid profile in both groups.

Statistical Analysis: SPSS for Windows version 20 (SPSS, Inc., Chicago, IL, USA) was employed for all statistical analyses.

RESULTS

In male hypertensive patients the serum lipid profile is higher as compare to control health male except HDL which is decreased in hypertensive patients and high in male control which have vasoprotective effect. The mean of total cholesterol (256.5 ± 12.9) is higher in male hypertensive patients as compare to healthy control. The mean of total LDL (mg\dl) (130.8 ± 21.5) is higher in male hypertensive patients as compare to healthy control. The mean of total Triglycerides (mg\dl) (190.2 ± 32.6) is higher in male hypertensive patients as compare to healthy control. The mean of total HDL (mg\dl) (30.6± 8.7) is lower in male hypertensive patients as compare to healthy control.

Table No.1:  Participant Characteristics

 

Male Hypertensive Patients (n=200)

Control (n=100)

Age (years)

51.4 + 10.2

49.7 + 10.3

Male

100

100

Body weight (Kg)

68.9 + 10.8

69.3 + 11.2

BMI (kg/m2)

24.7 + 2.6

24.5 + 2.5

Table No.2: Serum lipid profile in Male hypertensive male patients Control

Male hypertensive Patients (n=200)

Control  (n=100)

Fasting Blood Glucose(mg/dl)

96.8 ± 4.2

98.4 ± 4.9

Total Cholesterol (mg/dl)

256.5 ± 12.9

192.6 ± 31.5

LDL  (mg\dl)

130.8 ±  21.5

117.5± 18.6

HDL  (mg\dl)

30.6± 8.7

41.5 ± 9.1

Triglycerides (mg\dl)

190.2 ± 32.6

142.3 ± 31.7

DISCUSSION

In male population Coronary heart disease   is caused by high cholesterol. 18  another study showed   that  high  prevalence CHD in male population with hypertension and  high serum lipid profile there is association of  high  cholesterol with Coronary heart disease.19,20 Hypertension major risk factors for cardiovascular disease (CVD) are   dyslipidemia and Hypertension . Rate of death is high in low- and middle income countries at least 80%.In the developing countries, prevalence of hypertension is increasing globally it in developed countries the rate of death from hypertension is higher as compare to developed countries. High blood levels of low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides (TG) are attached with hypertension and CVD. In contrast, a risk factor for mortality from CVD is low level of high density lipoprotein (HDL). (Hypertension and coronary artery disease) has established association as Epidemiological studies. 34% is prevalence of hypertension among adult   worldwide. Major risk factors for CVD are decreased HDL and increased TC, TG, LDL. 7Reasons of Coronary heart disease in man population is Hyperlipidemia.  On the surface of the heart, there is four primary coronary arteries. CHD is   high ratio in man as compare women CHD is high in male population.  Reasons of cardiovascular disease are .Total cholesterol, triglyceride, HDL, LDL.

This study is conducted in the department of community medicine of Muhammad College of Medicine, Peshawar and Department of Biochemistry, Northwest school of medicine, Peshawar.  It was cross section –control study. Total 200 Male patients were selected male and 100 control health people are selected for the study. Lipid profile (Total cholesterol, HDL, VLDL and triglycerides) was estimated in both groups in male patient and control healthy people. Blood samples were collected from both groups’ male hypertensive patient   and health people. Samples were analyzed by Micro lab 300 for lipid profile for both groups male hypertensive patient and control .Merck kits were used for analysis of lipid profile in both groups. With high levels of cholesterol in blood circulation is associated with progression of heart disease. Risk factors of CHD are modifiable, high level of lipid is mostly occurring factor of Hypertension. By restriction of saturated fat and cholesterol, high blood cholesterol levels is decreased, with diet. 14HDL increase vasoprotective effects.21,22, In the present  study, in male hypertensive patients we  found  high level of cholesterol  as compare to control.23, 24 In male hypertensive patients the serum lipid profile is higher as compare to control health male  except HDL which is decreased  in hypertensive patients and high in male control which have vasoprotective effect. The mean of total cholesterol (256.5±12.9) is higher in male hypertensive patients as compare to healthy control.  The mean of total LDL (mg\dl) (130.8 ± 21.5) is higher in male hypertensive patients as compare to healthy control. The mean of total Triglycerides (mg\dl) (190.2±32.6) is higher in male hypertensive patients as compare to healthy control. The mean of total HDL (mg\dl) (30.6±8.7) is lower in male hypertensive patients as compare to healthy control. Moderate LDL-C reduction is best method to reduce hypertension.25 The ratio of LDL-C/HDL-C help us to CVD risk determine in male population.26

CONCLUSION

Male hypertensive patient found high level of serum lipid profile, so at high risk of cardiovascular diseases.  It is may be their life style or metabolic system.

Author’s Contribution:

Concept & Design of Study:

Rana Tauqir Ullah Khan

Drafting:

Fouzia Qadir, Muhammad Irfan Shereen

Data Analysis:

Muhammad Irfan Shereen

Revisiting Critically:

Rana Tauqir Ullah Khan, Fouzia Qadir

Final Approval of version:

Rana Tauqir Ullah Khan

Conflict of Interest: The study has no conflict of interest to declare by any author.

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