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  3. 17.The Predictive Significance of the Middle Cerebral to Umbilical Artery Doppler Ratio in Determining Neonatal Outcomes in Patients with Preeclampsia and Gestational Hypertension
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17.The Predictive Significance of the Middle Cerebral to Umbilical Artery Doppler Ratio in Determining Neonatal Outcomes in Patients with Preeclampsia and Gestational Hypertension

M. Rizwan Asghar1, Tayyiba Akhter1 and Aisha Asghar2

ABSTRACT

Objective: This study aimed to evaluate the predictive value of the middle cerebral to umbilical artery (MCA/UA) Doppler ratio in determining neonatal outcomes in patients with preeclampsia and gestational hypertension.

Study Design: Employed a retrospective cohort study

Place and Duration of Study: This study was conducted at the Fatima Memorial Hospital and Medical College Lahore from June 2022 to April 2023.

Materials and Methods: A total of 200 patients diagnosed with preeclampsia or gestational hypertension were included in this prospective cohort study. The MCA/UA Doppler ratio was calculated for each patient. Neonatal outcomes including intrauterine growth restriction (IUGR), preterm birth, fetal distress, neonatal intensive care unit (NICU) admission, and perinatal mortality were assessed.

Results: The mean MCA/UA Doppler ratio was 2.1 (SD = 0.3), with a range of 1.5 to 2.8. Higher MCA/UA ratios were significantly associated with an increased risk of IUGR (p < 0.001), preterm birth (p = 0.003), and fetal distress (p = 0.012). However, no significant associations were found between the MCA/UA ratio and NICU admission (p = 0.176) or perinatal mortality (p = 0.421). Subgroup analysis revealed that patients with severe hypertension had significantly higher MCA/UA ratios compared to those with moderate hypertension (p = 0.024).

Conclusion: The middle cerebral to umbilical artery Doppler ratio shows promise as a predictor of neonatal outcomes in patients with preeclampsia and gestational hypertension. Higher ratios are associated with an increased risk of adverse outcomes, including IUGR, preterm birth, and fetal distress. Incorporating the MCA/UA ratio into clinical practice may aid in risk stratification and guide management strategies to optimize perinatal outcomes in this high-risk population.

Key Words: Gestational, Hypertension, MCA, Birth, Population

Citation of article: Asghar MR, Akhter T, Asghar A. The Predictive Significance of the Middle Cerebral to Umbilical Artery Doppler Ratio in Determining Neonatal Outcomes in Patients with Preeclampsia and Gestational Hypertension, Med Forum 2023;34(6):73-77.