1. Aftab Ahmed Shaikh 2. Muhammad Bachal Pandhiani 3. Zaheer Ahmed Memon 

4. Haji Khan Khoharo

1.  Asstt. Prof. of Pharmacology, Faculty of Medicine and Allied Medical Sciences, Isra University, Hyderabad 

2.  Asstt. Prof. of Anatomy, Al-Tibri Medical College, Karachi 3. Asstt. Prof. of Anatomy, Faculty of Medicine and Allied Medical Sciences, Isra University, Hyderabad 4. Asstt. Prof. of Physiology/Medicine, Faculty of Medicine and Allied Medical Sciences, Isra University, Hyderabad

ABSTRACT

Objective:  To investigate the effects of orally administered monosodium glutamate (MSG) on the fallopian tube histology in adult female Wistar rat model.

Study Design:  Experimental/Analytical study

Place and Duration of Study: Animal House, Isra University Hyderabad from May to November 2013.  Materials and Methods: Forty adult male Wistar rats were divided into three groups; Group A. controls received 0.9% isotonic saline, Group B. received MSG orally (1.5 mg/kg), and Group C. received MSG orally (3 mg/kg). The animals were sacrificed after six weeks. Fallopian tubes were fixed in 4% formaldehyde, and were embedded in paraffin. Tissue sections of 5μ thicknesses were subjected to haematoxylin and eosin staining and were assessed by light microscopy. 

Results: The fallopian tubes (FT) of the control group A showed normal histological features. The fallopian tubes of the treated groups showed some cellular hypertrophy of the columnar epithelium, distortion of the basement membrane separating the endosalpinx from the myosalpinx. There were degenerative and atrophic changes observed in some parts; these were more pronounced in those that received 3 mg/kg body weight of MSG. There were marked vacuolations and lysed red blood cells, (3 mg/kg body weight treated rats) appearing in the  stroma cells

Conclusion: The monosodium glutamate may have deleterious effects on the fallopian tube histology in adult female Wistar rats particularly in high dose. Therefore caution must be taken for its frequent use in female because of possibility of female infertility.

Key words: Histology, Fallopian Tube, Monosodium Glutamate, Female Rat.