Sheharyar Ashraf, Jawad Hameed, Abid Haleem Khattak and Sajjad Orakzai

ABSTRACT

Objective: The study aims to predict the efficacy of dexamethasone alone and dexamethasone plus ondansetron in a pediatric population age range from 3 to 10 years old. This research is specifically designed for measuring the outcomes of PONV incidents among the pediatric population and confirm the success ratio of these two antiemetogenic drugs.

Study Design: Double-blinded randomized controlled trial study.  

Place and Duration of Study: This study was conducted at the Anesthesia and Critical Care Department Lady Reading Hospital-MTI Peshawar from January to December 2019.

132 patients in total, were selected for the study. Patients on physical status stage I and II described by the American Society of Anesthesia (ASA) were selected for this research.  We administer a 30mg dose of dipyrone NSAID as a placebo. Initially, 0.1 mg dose of ondansetron associated with dexamethasone was used later on dose was increased up to 4 mg whereas 0.15 mg dexamethasone was used alone.

Results: Postoperative vomiting was observed in 16 total cases, out of which the majority belonged to placebo and dexamethasone alone group (14.3% and 14% respectively). Little (6.8%) cases of postoperative vomiting were found among the ondansetron group. We did not find any significant statistical differences in our study. All the p values were greater than 0.05.

Conclusion: There is a need for routine administration of anti-emetogenic drugs among the high emetogenic risk surgeries in order to avoid PONV. Whereas in low emetogenic risk surgeries regular administration of prophylactic treatment is not much necessary.

Key Words: Postoperative Nausea and vomiting, Placebo study, Dexamethasone, Ondansetron plus dexamethasone.

Citation of article: Ashraf S, Hameed S, Khattak AH, Orakzai S. Comparison of the Prophylactic Effect of Dexamethasone, Ondansetron with the Combination of Dexamethasone on Decreasing Nausea and Vomiting