27. In-Hospital Outcomes of Acute Coronary Syndrome in Diabetic Versus Non-Diabetic
Muhammad Usama Khan, Sana Aslam and Hamna Javed
ABSTRACT
Objective: In present study we evaluated the in-hospital outcomes of Acute Coronary Syndrome in diabetic versus non-diabetic patients.
Study Design: Descriptive / comparative study.
Place and Duration of Study: This study was conducted at the Department of Coronary Care Unit, DHQ hospital Kasur from November 1st 2016 to April 30th 2017.
Materials and Methods:A total number of one hundred and fifty (150) patients who presented with acute coronary syndrome were included. Patient who presented with ACS between November 2016 to April 2017 were included in this analysis. Diagnosis of diabetes mellitus was based on previous history of patients of patients (i.e. a patient already taking oral or subcutaneous diabetic treatment) or new diagnosis of diabetes mellitus on routine clinical labs (fasting blood sugar levels >125 mg/dl). Development of left ventricular failure, cardiogenic shock, and in-hospital mortality were the primary study endpoints.
Inclusion and Exclusion Criteria: Patients who were presented with ST segment elevation myocardial infarction and non-ST segment elevation myocardial infarction were included. Patients with stable angina pectoris were excluded Results: Out of 150 patients, 72 (48.0%) patients were diabetic and 78 (52.0%) patients were non-diabetic. 63 (87.5%) diabetic patients were presented with acute ST-elevation myocardial infarction (STEMI) and 9 (12.5%) were presented with non-ST elevation myocardial infarction (non-STEMI). While there were 71 (91.0%) nondiabetic patients who were presented with STEMI and 7 (9.0%) with non-STEMI (p-value 0.48). Regarding inhospital outcomes of study patients. left ventricular (LV) failure occurred in 17 (23.6%) diabetic patients and in only 7 (9.0%) non-diabetic patients (p-value 0.01). incidence of occurrence of cardiogenic shock was not-significantly different between the patients (p-value 0.20). However, in-hospital mortality was very high in diabetic patients 12 (16.7%) versus only 4 (5.1%) in non-diabetic patients (p-value 0.02).
Conclusion: Diabetes mellitus significantly increases the risk of LV failure and in-hospital mortality in patients with acute Coronary Syndrome.
Key Words: Diabetes mellitus, acute coronary syndrome, in-hospital mortality.
Citation of article: Khan MU, Aslam S, Javed H. In-Hospital Outcomes of Acute Coronary Syndrome in Diabetic Versus Non-Diabetic. Med Forum 2017;28(6):105-108.