40. Histopathological Analysis of Renal Tissue to Evaluate the Effects of Proton Pump Inhibitors at Cellular Level
Muhammad Javed1, Amna Mubeen1 and Nusrat Manzoor2
ABSTRACT
Objective: To evaluate the cytopathological effects of proton pump inhibitors on renal tissue in different doses by using an animal model
Study Design: Randomized control trial.
Place and duration of study: This study was conducted at Post Graduate Medical Institute Lahore for a period
of 4 weeks.
Materials and Methods: The sample size was 60 mice. The sampling technique was Simple Random Sampling. The mice were obtained from National Institute of Health Islamabad. The animals were kept in labeled cages under standard environmental conditions. Animals were divided into three groups. One group served as control and the other two served as treated groups. Micrometry was done to evaluate the effects of drug.
Results: It was observed on study of histological sections that proton pump inhibitors induce toxic effects on cells of uriniferous tubules of kidney. The tubular cells showed varying degree of tubular atrophy.
Conclusion: The observations of the study revealed that it damages the uriniferous tubules by causing their atrophy leading to renal insufficiency. It is desired that these result will generate awareness about the careful use of the proton pump inhibitors by the people and the clinicians.
Key Words: Cytopathology, Renal toxicity, Atrophy
Citation of article: Javed M , Mubeen A, Manzoor N. Histopathological Analysis of Renal Tissue to Evaluate the Effects of Proton Pump Inhibitors at Cellular Level. Med Forum 2017;28(3):160-163.